Eric Bledsoe matched his season high with 27 points and Giannis Antetokounmpo added 15 in Milwaukee's victory over Detroit.
Milwaukee countered an opening basket with nine consecutive points and did not trail after that.
The Bucks led 30-21 after one quarter, 56-45 at halftime and then opened the third period with a 19-4 run.
Blake Griffin had 31 points for the Pistons.