We've compiled four of the most memorable games in the history of the rivalry.
1. October, 13 1990
No.1 ranked Wolverines scored with 6 seconds left in the game against the Spartans, but still trailed by 1 point.
They decided to go for a two-point conversion and U-M receiver Desmond Howard outran MSU cornerback Eddie Brown for a wide open catch.
Prepared to win the game, Howard lined up for the catch, and Brown tripped him making for a Spartan win, 28-27.
2. October 9, 1999
Anyone remember the days of Bill Burke?
The Spartans and the Wolverines, both top 10 undefeated teams, went head-to-head in what was shaping up to be a blowout.
That is until U-M senior Tom Brady turned the game into a exciting show with two late drive touchdowns.
It wasn't enough to bring the wolverines a victory, but it did bring the final score to 31-34.
3. November 3, 2001
How about the time Bob Stehlin stopped the clock at :01, allowing for one final pass to the back of the end zone where T.J. Duckett was waiting to score the game winning touchdown for a 26-24 victory in East Lansing.
4. October 17, 2015
Ahead by 2 with 10 seconds left on the clock, all the Wolverines had to do was punt the ball to MSU.
The snap was low, and when punter Blake O’Neill tried to punt the ball, he was brought down by MSU, sending the toss right into the hands of MSU’s red-shirt freshman Jalen Watts-Jackson.
Never before having touched the ball in a college football game, the safety took off running.
The clock hit zero while Watts-Jackson was running, but defense held strong allowing a last second victory for MSU, 27-23.
Did your most memorable Michigan-Michigan State moment make our list?